Mass Spectrometry Proteomics
(Advanced Technology Core Laboratories, Dan L. Duncan Cancer Center)
Research Core

Baylor College of Medicine
Jewish Institute for Medical Research

Physical Address
One Baylor Plaza
1st Floor Jones Building 108C
Houston, Texas 77030

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The Mass Spectrometry-Proteomics Core Laboratory (MS-PCL) of Baylor College of Medicine provides services for high sensitivity high throughput triple Time-of-Flight mass spectrometer and full-fledged proteomics technologies for discovery and validation of biomarkers of various diseases. The services include (i) rapid mass determination of proteins and peptides, (ii) identification of proteins/peptides in complex biological samples, (iii) subproteome isolation and characterization, and (iv) detailed analysis of post-translational modification of proteins/peptides. The MS-PCL is also planning to meet the Good Laboratory Practice.

  • Charge for services or equipment: Yes
  • Equipment Training: No
  • Methodology Training: No

Services

  • 2D gel electrophoresis
  • Accurate mass determination of proteins or biomolecules
  • Depletion of highly abundant proteins in serum/plasma
  • DIGE labeling and 2D gel electrophoresis
  • Glycoproteome enrichment
  • High-throughput identification of proteins in complex samples
  • ITRAQ labeling, profiling, and quantitation
  • Multiple Reaction Monitoring (MRM) of biological samples
  • Peptide sequencing using tandem mass spectrometry
  • Phosphoproteome enrichment
  • Post-translational modification analysis of proteins/peptides
  • Protein/peptide QC
  • Spot cutting and protein identification
  • Strong cation exchange liquid chromatography

Equipment

  • AB SCIEX TripleTOF 5600 mass spectrometer
  • Agilent 1200 capillary LC system
  • Agilent OFFgel isoelectric focusing system
  • BioRad Versadoc 4000MP gel imaging system
  • Biotek Synergy 2 plate reader
  • Eksigen nanoLC-Ultra 2D system
  • OFFgel liquid phase isoelectric focusing

Categories

, Proteomics and Mass Spectrometry

VIICTR Member Organizations
  • Baylor College of Medicine
  • Texas Children's Hospital
  • MD Anderson Cancer Center
  • Michael E. DeBakey VA Medical Center
  • Ben Taub Hospital
  • University of Houston College of Pharmacy
  • Gulf Coast Consortia